Osteoarticular infection caused by Talaromyces Marneffei and Salmonella in a person living with HIV: a case report

BMC Infectious Diseases

Case Report

Mengyan Wang¹  Lele Yu¹  Hu Wan¹  Binhai Zhang¹  Jinchuan Shi¹ 

[1] Department II of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, China;

关键词: Talaromyces marneffei;    Salmonella;    HIV;    Case report;    NGS;   

DOI  :  10.1186/s12879-023-08554-9

 received in 2023-02-16, accepted in 2023-08-22,  发布年份 2023

来源: Springer

【 摘 要 】

IntroductionTalaromycosis is a common invasive fungal disease in patients with HIV. However, its association with bone destruction is unusual in AIDS patients with talaromycosis.Case PresentationThis report covers the case of a 38-year-old male AIDS patient coinfected with Talaromyces marneffei and Salmonella. The case, which involved bone destruction, was identified via metagenomic next-generation sequencing (mNGS). Following treatment with a combination of amphotericin B and piperacillin-tazobactam, the patient’s elbow motion noticeably improved. Imaging findings revealed that the progression of bony destruction had halted.ConclusionBone damage due to Talaromyces marneffei infection is infrequent in HIV-positive patients. Therefore, healthcare professionals must be vigilant for potential bone lesions associated with this type of infection. Prompt diagnosis and antimicrobial treatment are crucial.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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