PhSeZnCl in the Synthesis of Steroidal β-Hydroxy-Phenylselenides Having Antibacterial Activity

International Journal of Molecular Sciences

Katarzyna Niemirowicz-Laskowska¹  Robert Bucki¹  Claudio Santi²  Bonifacio Monti²  Leszek Siergiejczyk³  PawelAdam Grzes³  Stefano Mellea³  Izabella Jastrzebska³  Valerio Salerno³ 

[1] Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystok, ul. Mickiewicza 2C, 15-222 Bialystok, Poland;Group of Catalysis and Organic Green Chemistry–Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06132 Perugia, Italy;Institute of Chemistry, University of Białystok, ul. Ciołkowskiego 1K, 15-245 Białystok, Poland;

关键词: steroids;    selenium;    antibacterial;    antibiofilm;   

DOI  :  10.3390/ijms20092121

来源: DOAJ

【 摘 要 】

We report here the reaction of in situ prepared PhSeZnCl with steroid derivatives having an epoxide as an electrophilic functionalization. The corresponding ring-opening reaction resulted to be regio- and stereoselective affording to novel phenylselenium-substituted steroids. Assessment of their antibacterial properties against multidrug-resistant bacteria, such as Pseudomonas aeruginosa Xen 5 strain, indicates an interesting bactericidal activity and their ability to prevent bacterial biofilm formation.

【 授权许可】

Unknown