Nutritional ketosis for mild cognitive impairment in Parkinson's disease: A controlled pilot trial

Clinical Parkinsonism & Related Disorders

卷:1

Marcelle D. Shidler¹  Richard S. Isaacson¹  Patrick G. Sullivan²  Suzanne S. Summer³  Alberto J. Espay⁴  Andrew P. Duker⁵  Robert Krikorian⁵ 

[1] Behavioral Neuroscience, University of Cincinnati Academic Health Center, Cincinnati, OH, USA;

[2] Behavioral Neuroscience, University of Cincinnati Academic Health Center, P.O. Box 670559, Cincinnati, OH 45267-0559, USA.;

[3] Corresponding author at: Department of Psychiatry &

[4] Clinical Translational Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA;

[5] Department of Psychiatry &

关键词: Parkinson's disease;    Mild cognitive impairment;    Memory;    Nutritional ketosis;    Carbohydrate restriction;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: Glucose hypometabolism and insulin resistance increase risk for and accelerate progression in Parkinson's disease and neurocognitive disorders. We conducted a proof of concept trial to determine whether ketogenesis, a metabolic adaptation induced by dietary carbohydrate restriction, can improve cognitive performance in Parkinson's disease patients with mild cognitive impairment. Methods: We enrolled patients with mild cognitive impairment associated with Parkinson's disease in an eight-week nutritional intervention with random assignment to either high-carbohydrate consumption typical of the Western dietary pattern (n = 7) or to a low-carbohydrate, ketogenic regimen (n = 7). We assessed changes in cognitive performance as well as motor function, anthropometrics, and metabolic parameters. Results: Relative to the high-carbohydrate group, the low-carbohydrate group demonstrated improvements in lexical access (p = 0.02, Cohen's f effect size = 0.76) and memory (p = 0.01, f = 0.87) and as well as a trend for reduced interference in memory (p = 0.06, f = 0.60). The low-carbohydrate group also exhibited reduced body weight (p < 0.0001, f = 1.89) and increased circulation of beta-hydroxybutyrate (p = 0.01, f = 0.90). Change in body weight was strongly associated with memory performance (p = 0.001). Motor function was not affected by the intervention. Conclusion: Nutritional ketosis enhanced cognitive performance in Parkinson's disease-associated mild cognitive impairment in this pilot study. This metabolic intervention and its mechanisms deserve further investigation in the context of neurodegeneration.

【 授权许可】

Unknown