Clinical Parkinsonism & Related Disorders | |
Neural synchronization analysis of electroencephalography coherence in patients with Parkinson’s disease-related mild cognitive impairment | |
Maki Ozaki1  Kaoru Kinugawa2  Hiroshi Kataoka3  Tomoo Mano3  Kazuma Sugie3  | |
[1] Corresponding author at: Department of Neurology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.;Department of Rehabilitation Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan;Department of Neurology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan; | |
关键词: Parkinson's disease; Mild cognitive impairment; Electroencephalography; Time–frequency analysis; Coherence analysis; | |
DOI : | |
来源: DOAJ |
【 摘 要 】
Introduction: The underlying pathophysiology of slight cognitive dysfunction in Parkinson’s disease-related mild cognitive impairment (PD-MCI) is yet to be elucidated. Our study aimed to evaluate the association between cognitive function and brain functional connectivity (FC) in patients with PD-MCI. Methods: Twenty patients with sporadic PD-MCI were evaluated for FC in the brain network. Further, electroencephalography (EEG) coherence analysis in the whole-brain and quantified regional coherence using phase coupling were performed for each frequency, and motor and cognitive function were assessed in the whole-brain. Results: The degree of cognitive impairment was related to a decrease in the coherence in the alpha ranges. The regional coherence in the left frontal-left parietal region rather than the right frontal-right parietal region showed a higher correlation with the cognitive function scores. Conclusion: The differences in EEG coherence across different types of cognitive dysfunction reflect a compensatory response to the heterogeneous and complex clinical presentation of PD-MCI. Our findings indicate decreased brain efficiency and impaired neural synchronization in PD-MCI; these results may be crucial in elucidating the pathological exacerbation of PD-MCI.
【 授权许可】
Unknown