Neural synchronization analysis of electroencephalography coherence in patients with Parkinson’s disease-related mild cognitive impairment

Clinical Parkinsonism & Related Disorders

Maki Ozaki¹  Kaoru Kinugawa²  Hiroshi Kataoka³  Tomoo Mano³  Kazuma Sugie³ 

[1] Corresponding author at: Department of Neurology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.;Department of Rehabilitation Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan;Department of Neurology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan;

关键词: Parkinson's disease;    Mild cognitive impairment;    Electroencephalography;    Time–frequency analysis;    Coherence analysis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: The underlying pathophysiology of slight cognitive dysfunction in Parkinson’s disease-related mild cognitive impairment (PD-MCI) is yet to be elucidated. Our study aimed to evaluate the association between cognitive function and brain functional connectivity (FC) in patients with PD-MCI. Methods: Twenty patients with sporadic PD-MCI were evaluated for FC in the brain network. Further, electroencephalography (EEG) coherence analysis in the whole-brain and quantified regional coherence using phase coupling were performed for each frequency, and motor and cognitive function were assessed in the whole-brain. Results: The degree of cognitive impairment was related to a decrease in the coherence in the alpha ranges. The regional coherence in the left frontal-left parietal region rather than the right frontal-right parietal region showed a higher correlation with the cognitive function scores. Conclusion: The differences in EEG coherence across different types of cognitive dysfunction reflect a compensatory response to the heterogeneous and complex clinical presentation of PD-MCI. Our findings indicate decreased brain efficiency and impaired neural synchronization in PD-MCI; these results may be crucial in elucidating the pathological exacerbation of PD-MCI.

【 授权许可】

Unknown