Event‐related potentials during sustained attention and memory tasks: Utility as biomarkers for mild cognitive impairment

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Shani Waninger¹  Chris Berka¹  Marija S. Karic¹  Amir Meghdadi¹  Kimberly Stevens²  David H. Salat²  Cinthya Aguero²  Tatiana Sitnikova²  Ajay Verma³ 

[1] Advanced Brain Monitoring, Inc.CarlsbadCAUSA;MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical ImagingDepartment of RadiologyMassachusetts General HospitalCharlestownMAUSA;United NeuroscienceDublinIreland;

关键词: Mild cognitive impairment;    Neurophysiology;    Electroencephalography;    Event‐related potential;    Biomarker;   

DOI  :  10.1016/j.dadm.2018.05.007

来源: DOAJ

【 摘 要 】

Abstract Introduction The objective of the study is to validate attention and memory tasks that elicit event‐related potentials (ERPs) for utility as sensitive biomarkers for early dementia. Methods A 3‐choice vigilance task designed to evaluate sustained attention and standard image recognition memory task designed to evaluate attention, encoding, and image recognition memory were administered with concurrent electroencephalography acquisition to elicit ERPs in mild cognitive impairment (MCI) and healthy cohorts. ERPs were averaged, and mean or maximum amplitude of components was measured and compared between and within cohorts. Results There was significant suppression of the amplitude of the late positive potential in the MCI cohort compared with the healthy controls during 3‐choice vigilance task, predominantly over occipital and right temporal‐parietal region, and standard image recognition memory task over all regions. During standard image recognition memory task, diminished performance showed strong correlation with electroencephalography measurements. The old/new effects observed in the healthy controls cohort correlated with performance and were lost in MCI. Discussion ERPs obtained during cognitive tasks may provide a powerful tool for assessing MCI and have strong potential as sensitive and robust biomarkers for tracking disease progression and evaluating response to investigative therapeutics.

【 授权许可】

Unknown