The Fast Cognitive Evaluation (FaCE): a screening tool to detect cognitive impairment in patients with cancer

BMC Cancer

Research

Amel Baghdadli¹  Bruno Gagnon²  Lynn R. Gauthier²  Pierre Gagnon³  Giovanni G. Arcuri⁴  Clarence G. Green⁵ 

[1] CHU de Québec-Université Laval Research Centre, Québec City, QC, Canada;Montreal University Hospital Center (CHUM) Research Centre, Montreal, QC, Canada;CHU de Québec-Université Laval Research Centre, Québec City, QC, Canada;Équipe de recherche Michel-Sarrazin en oncologie psychosociale et soins palliatifs, Québec City, QC, Canada;Department of Family and Emergency Medicine, Faculty of Medicine, Université Laval, Québec City, QC, Canada;Université Laval Cancer Research Centre, Québec City, QC, Canada;Réseau Québécois de recherche en soins palliatifs et de fin de vie du FRQS (RQSPAL), Québec City, QC, Canada;VITAM-Centre de recherche en Santé Durable, Université Laval, Québec City, QC, Canada;CHU de Québec-Université Laval Research Centre, Québec City, QC, Canada;Équipe de recherche Michel-Sarrazin en oncologie psychosociale et soins palliatifs, Québec City, QC, Canada;Université Laval Cancer Research Centre, Québec City, QC, Canada;Réseau Québécois de recherche en soins palliatifs et de fin de vie du FRQS (RQSPAL), Québec City, QC, Canada;VITAM-Centre de recherche en Santé Durable, Université Laval, Québec City, QC, Canada;Department of Psychiatry and Neurosciences, Université Laval, Québec City, QC, Canada;Faculty of Medicine and Health Sciences, School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada;Federation University Australia, Berwick, Melbourne, Vic, Australia;

关键词: Chemo brain;    Brain fog;    Cognition;    Cancer;    Mild cognitive impairment;    Memory;   

DOI  :  10.1186/s12885-022-10470-1

 received in 2022-06-24, accepted in 2022-12-21,  发布年份 2022

来源: Springer

【 摘 要 】

Cancer-related cognitive impairment (CRCI) is one of the most concerning conditions experienced by patients living with cancer and has a major impact on their quality of life. Available cognitive assessment tools are too time consuming for day-to-day clinical setting assessments. Importantly, although shorter, screening tools such as the Montreal Cognitive Assessment or the Mini-Mental State Evaluation have demonstrated a ceiling effect in persons with cancer, and thus fail to detect subtle cognitive changes expected in patients with CRCI. This study addresses this lack of cognitive screening tools by developing a novel tool, the Fast Cognitive Evaluation (FaCE).A population of 245 patients with 11 types of cancer at different illness and treatment time-points was enrolled for the analysis. FaCE was developed using Rasch Measurement Theory, a model that establishes the conditions for a measurement tool to be considered a rating scale.FaCE shows excellent psychometric properties. The population size was large enough to test the set of items (item-reliability-index=0.96). Person-reliability (0.65) and person-separation (1.37) indexes indicate excellent internal consistency. FaCE’s scale is accurate (reliable) with high discriminant ability between cognitive levels. Within the average testing time of five minutes, FaCE assesses the main cognitive domains affected in CRCI.FaCE is a rapid, reliable, and sensitive tool for detecting even minimal cognitive changes over time. This can contribute to early and appropriate interventions for better quality of life in patients with CRCI. In addition, FaCE could be used as a measurement tool in research exploring cognitive disorders in cancer survivors.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

12888_2022_4443_Article_IEq1.gif

41116_2022_35_Article_IEq397.gif

41116_2022_35_Article_IEq395.gif

Fig. 2

41116_2022_35_Article_IEq383.gif

41116_2022_35_Article_IEq379.gif