Molecular Medicine: Synthesis and In Vivo Detection of Agents for use in Boron Neutron Capture Therapy. Final Report

Kabalka, G. W.

University of Tennessee Graduate School of Medicine

关键词: Isotopes;    Cancer;    Neoplasms;    Synthesis;    Tomography Neutron Capture;   

DOI  :  10.2172/909601
RP-ID  :  DOE/ER/62189-5
RP-ID  :  FG02-96ER62189
RP-ID  :  909601

美国|英语

来源: UNT Digital Library

【 摘 要 】

The primary objective of the project was the development of in vivo methods for the detection and evaluation of tumors in humans. The project was focused on utilizing positron emission tomography (PET) to monitor the distribution and pharamacokinetics of a current boron neutron capture therapy (BNCT) agent, p-boronophenylalanine (BPA) by labeling it with a fluorine-18, a positron emitting isotope. The PET data was then used to develop enhanced treatment planning protocols. The study also involved the synthesis of new tumor selective BNCTagents that could be labeled with radioactive nuclides for the in vivo detection of boron.