Crosstalk between autophagy and DNA repair systems

Turkish journal of biology

article

SİNEM SARIKAYA¹  HATİCE ÇAKIR¹  DEVRİM GÖZÜAÇIK¹  YUNUS AKKOdz 

[1] SUNUM Nanotechnology Research and Application Center;Koç University School of Medicine;Koç University Research Center for Translational Medicine (KUTTAM)

关键词: Autophagy;    DNA damage;    DDR;    DNA repair;   

DOI  :  10.3906/biy-2103-51

学科分类：生物科学（综合）

来源: Scientific and Technical Research Council of Turkey - TUBITAK

【 摘 要 】

Autophagy and DNA repair are two essential biological mechanisms that maintain cellular homeostasis. Impairment of these mechanisms was associated with several pathologies such as premature aging, neurodegenerative diseases, and cancer. Intrinsic or extrinsic stress stimuli (e.g., reactive oxygen species or ionizing radiation) cause DNA damage. As a biological stress response, autophagy is activated following insults that threaten DNA integrity. Hence, in collaboration with DNA damage repair and response mechanisms, autophagy contributes to the maintenance of genomic stability and integrity. Yet, connections and interactions between these two systems are not fully understood. In this review article, current status of the associations and crosstalk between autophagy and DNA repair systems is documented and discussed.

【 授权许可】

Unknown