Roles of DNA damage in renal tubular epithelial cells injury

Frontiers in Physiology

Physiology

Jing Ouyang¹  Aihua Zhang¹  Zhanjun Jia¹  Peipei Wang¹  Yunwen Yang¹ 

[1] Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China;Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China;Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China;

关键词: DNA damage;    tubular epithelial cells;    DNA repair;    DDR;    AKI (acute kidney injury);    CKD—chronic kidney disease;   

DOI  :  10.3389/fphys.2023.1162546

 received in 2023-02-09, accepted in 2023-03-29,  发布年份 2023

来源: Frontiers

【 摘 要 】

The prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking. DNA damage and the related DNA damage response (DDR) have been confirmed as common pathogenesis of acute kidney injury and chronic kidney disease. Reactive oxygen species (ROS) induced DNA damage is one of the most common types of DNA damage involved in the pathogenesis of acute kidney injury and chronic kidney disease. In recent years, several developments have been made in the field of DNA damage. Herein, we review the roles and developments of DNA damage and DNA damage response in renal tubular epithelial cell injury in acute kidney injury and chronic kidney disease. In this review, we conclude that focusing on DNA damage and DNA damage response may provide valuable diagnostic biomarkers and treatment strategies for renal diseases including acute kidney injury and chronic kidney disease.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Ouyang, Jia, Zhang and Yang.