Nanoparticles as Potential Novel Therapies for Urinary Tract Infections

Frontiers in Cellular and Infection Microbiology

Johanna Catalán-Figueroa¹  Nicolás Navarro²  Sofía V. Sánchez²  Javier O. Morales² 

[1] Departamento Farmacología, Facultad de Ciencias Químicas, Instituto de Farmacología experimental de Córdoba (IFEC-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina;Facultad de Medicina, Escuela de Química y Farmacia, Universidad Católica del Maule, Talca, Chile;Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile;Center of New Drugs for Hypertension (CENDHY), Santiago, Chile;Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile;

关键词: urinary tract infection therapies;    composite materials;    antibacterial;    antibiofilm;    organic nanoparticles;    inorganic nanoparticles;   

DOI  :  10.3389/fcimb.2021.656496

来源: Frontiers

【 摘 要 】

Urinary tract infection (UTI) is one of the most common reasons for antibiotic treatment. Nevertheless, uropathogens are steadily becoming resistant to currently available therapies. In this context, nanotechnology emerges as an innovative and promising approach among diverse strategies currently under development. In this review we deeply discuss different nanoparticles (NPs) used in UTI treatment, including organic NPs, nanodiamonds, chemical and green synthesized inorganic NPs, and NPs made of composite materials. In addition, we compare the effects of different NPs against uropathogens in vivo and in vitro and discuss their potential impact the in the near future.

【 授权许可】

CC BY