Química Nova | |
Desenvolvimento e validação de método analítico para quantificação do fármaco bevacizumabe por cromatografia a líquido de alta eficiência | |
Elionai Cassiana De Lima Gomes2  Armando Da Silva Cunha Júnior2  Maria Irene Yoshida1  Rodrigo Jorge1  | |
[1] ,Universidade Federal de Minas Gerais Faculdade de Farmácia Belo Horizonte MG ,Brasil | |
关键词: bevacizumab; high performance liquid chromatography; validation; | |
DOI : 10.1590/S0100-40422012000300029 | |
来源: SciELO | |
【 摘 要 】
In this study, an analytical method was developed and validated for quantitation of the drug bevacizumab (Avastin®) by high performance liquid chromatography (HPLC). The HPLC column was a BioSuite 250® HR SEC, 300 x 7.8 mm x 5 µm (Waters, USA). The mobile phase consisted of phosphate buffered saline (PBS). The results revealed that the method was specific, precise, accurate, robust and linear (r² = 0.998) from 5 to 75 µg mL-1. Therefore, this method can be used in drug release studies or in quality control ampoules of the drug.
【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
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RO202103040063864ZK.pdf | 290KB | download |