期刊论文详细信息
Quimica nova | |
Development and validation of an analytical method for quantitation of the drug bevacizumab by high performance liquid chromatography | |
Yoshida, Maria Irene1  Gomes, Elionai Cassiana de Lima1  Cunha Júnior, Armando da Silva1  Jorge, Rodrigo2  | |
[1] Universidade Federal de Minas Gerais, Belo Horizonte, Brasil;Universidade de São Paulo, Ribeirão Preto, Brasil | |
关键词: bevacizumab; high performance liquid chromatography; validation.; | |
DOI : 10.1590/S0100-40422012000300029 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
In this study,an analytical method was developed and validated for quantitation of the drugbevacizumab (Avastin®) by high performance liquid chromatography(HPLC). The HPLC column was a BioSuite 250® HR SEC, 300 x 7.8mm x 5 µm (Waters, USA). The mobile phase consisted of phosphate bufferedsaline (PBS). The results revealed that the method was specific, precise, accurate,robust and linear (r2 = 0.998) from 5 to 75 µg mL-1.Therefore, this method can be used in drug release studies or in quality controlampoules of the drug.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO201902010317768ZK.pdf | 290KB | download |