High frequency of resistance to the drugs isoniazid and rifampicin among tuberculosis cases in the city of Cabo de Santo Agostinho, an urban area in Northeastern Brazil

Revista da Sociedade Brasileira de Medicina Tropical

Marcilio Baliza²  Artur Henrique Bach²  Gabriel Lobo De Queiroz²  Inês Cardoso Melo¹  Maria Madileuza Carneiro¹  Maria De Fátima Pessoa Militão De Albuquerque²  Philip Suffys¹  Laura Rodrigues¹  Ricardo Ximenes¹  Norma Lucena-silva¹ 

[1] ,Fundação Oswaldo Cruz Centro de Pesquisas Aggeu Magalhães Departamento de ImunologiaRecife PE

关键词: Tuberculosis;    Drug resistance;    Multidrug resistance;    Risk factors;    Tuberculose;    Resistência a drogas;    Multidroga resistência;    Fatores de risco;   

DOI  :  10.1590/S0037-86822008000100003

来源: SciELO

【 摘 要 】

The objective of the present study was to investigate the frequency and risk factors for developing multidrug-resistant tuberculosis in Cabo de Santo Agostinho, PE. This was a prospective study conducted from 2000 to 2003, in which suspected cases were investigated using bacilloscopy and culturing. Out of 232 confirmed cases of tuberculosis, culturing and antibiotic susceptibility tests were performed on 174. Thirty-five of the 174 cultures showed resistance to all drugs. The frequencies of primary and acquired resistance to any drug were 14% and 50% respectively, while the frequencies of primary and acquired multidrug resistance were 8.3% and 40%. Previous tuberculosis treatment and abandonment of treatment were risk factors for drug resistance. The high levels of primary and acquired resistance to the combination of isoniazid and rifampicin contributed towards the difficulties in controlling tuberculosis transmission in the city.

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