期刊论文详细信息
Revista da Sociedade Brasileira de Medicina Tropical
High frequency of resistance to the drugs isoniazid and rifampicin among tuberculosis cases in the city of Cabo de Santo Agostinho, an urban area in Northeastern Brazil
Fundação Oswaldo Cruz, Recife1  Secretaria de Saúde do Cabo de Santo Agostinho, Cabo de Santo Agostinho1  Secretaria de Saúde do Estado de Pernambuco, Recife1  Ximenes, Ricardo1  Bach, Artur Henrique1  Baliza, Marcilio1  Fundação Oswaldo Cruz, Rio de Janeiro1  Instituto Materno Infantil Prof. Fernando Figueira1  Queiroz, Gabriel Lobo de1  London School of Hygiene Tropical Medicine, London1  Melo, Inês Cardoso1  Carneiro, Maria Madileuza1  Universidade Federal do Recôncavo da Bahia, Santo Antônio de Jesus1  Rodrigues, Laura1  Lucena-Silva, Norma1  Suffys, Philip1  Albuquerque, Maria de Fátima Pessoa Militão de1 
关键词: Tuberculosis;    Drug resistance;    Multidrug resistance;    Risk factors;   
DOI  :  10.1590/S0037-86822008000100003
学科分类:农业科学(综合)
来源: Sociedade Brasileira de Medicina Tropical
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【 摘 要 】

The objective of the present study was to investigate the frequency and risk factors for developing multidrug-resistant tuberculosis in Cabo de Santo Agostinho, PE. This was a prospective study conducted from 2000 to 2003, in which suspected cases were investigated using bacilloscopy and culturing. Out of 232 confirmed cases of tuberculosis, culturing and antibiotic susceptibility tests were performed on 174. Thirty-five of the 174 cultures showed resistance to all drugs. The frequencies of primary and acquired resistance to any drug were 14% and 50% respectively, while the frequencies of primary and acquired multidrug resistance were 8.3% and 40%. Previous tuberculosis treatment and abandonment of treatment were risk factors for drug resistance. The high levels of primary and acquired resistance to the combination of isoniazid and rifampicin contributed towards the difficulties in controlling tuberculosis transmission in the city.

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