Drug resistance of M. Tuberculosis isolated from patients with HIV infection seen at an AIDS Reference Center in São Paulo, Brazil

Revista do Instituto de Medicina Tropical de São Paulo

Walkyria P Pinto²  David J Hadad²  M. Cecília A Palhares²  Lucilaine Ferrazoli¹  M. Alice S. Telles¹  Sueli Y.m. Ueki¹  Márcia T. F. Santos²  Ana L. N. Placco²  Naim Sauaia¹  Moisés Palac¹ 

[1] ,Health Department of the State of São Paulo Reference and Training Center São Paulo SP ,Brazil

关键词: Tuberculosis;    Tuberculosis treatment;    AIDS;    Multidrug resistance;    Drug resistance;    HIV infection;   

DOI  :  10.1590/S0036-46651996000100004

来源: SciELO

【 摘 要 】

M. tuberculosis-positive cultures were obtained from 228 patients seen in our service and drug sensitivity assays were carried out from January 1992 to December 1994. A survey of the medical records of these patients showed resistance to one or more drugs in 47 (20.6%), 25 of whom (10.9%), who reported previous treatment, were considered to have acquired resistance. Among the antecedents investigated, only previous treatment and alcoholism were the factors independently associated with the occurrence of resistance. The survival of patients with resistant strains was lower than that of patients attacked by non-resistant M. tuberculosis. We conclude that in the present series M. tuberculosis resistance to tuberculostatic agents was predominantly of the acquired type.

【 授权许可】

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