Anticancer potential of kebar grass (Biophytum petersianum), an Indonesian traditional medicine

International Conference on Food Science and Technology

Darwati, I.^1 ; Nurcahyanti, A.^2 ; Trisilawati, O.^1 ; Nurhayati, H.^1 ; Bermawie, N.^3 ; Wink, M.^2

Department of Ecophysiology, Indonesian Spices and Medicinal Crops Research Institute, Indonesian Agency for Agricultural Research and Development (IAARD), Indonesia^1

Biology Department, Institute of Pharmacy and Molecular Biology (IPMB), Heidelberg University, Germany^2

Department of Plant Genetic Resources and Breeding, Indonesian Spices and Medicinal Crops Research Institute, Indonesian Agency for Agricultural Research and Development (IAARD), Indonesia^3

关键词: Anti-oxidant activities;    Anticancer potentials;    Cervical cancer cells;    Cytotoxic activities;    kebar grass;    Lymphocytic leukemia;    Multidrug resistance;    Pancreatic carcinoma;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/292/1/012063/pdf
DOI  :  10.1088/1755-1315/292/1/012063

来源: IOP

【 摘 要 】

Biophytum petersianum Klotzsch (kebar grass) has been used in Indonesia as traditional medicine. The objective of the current study was to evaluate the cytotoxic activity against several human cancer cells. The plants were collected from Purworejo, Central Java, Indonesia and extracted using methanol and dichlormethane. The extracts were analyzed for its antioxidant activity using DPPH (2,2 diphenyl-1-picrylhydrazyl) method. Cytotoxicity was examined against human acute lymphocytic leukemia cell (CCRF-CEM), multidrug resistance human acute leukemia cell (CEM/ADR5000), human cervical cancer cell (HeLa), human pancreatic carcinoma (Mia-PaCa2) and breast cancer cell (MCF-7) using colorimetric assay for assessing cell viability. The results indicated that methanol extract exhibited higher antioxidant activity as compared to dichlormethane extract. Both extracts exhibited moderate cytotoxicity against several human cancer cells, such as those of CCRF-CEM, CEM/ADR500, Mia-PaCa2 and MCF. This finding was the first report suggested that kebar grass from Purworejo, Central Java, Indonesia was potential as antioxidant and anticancer. Further comprehensive studies on the mechanism of actions are necessary to support this finding.