Cytotoxicity of Crude Lectins from Red Macroalgae from the Southern Coast of Java Island, Gunung Kidul Regency, Yogyakarta, Indonesia

International Conference On Food Science and Engineering 2016

Anam, C.^1,3 ; Chasanah, E.^2 ; Perdhana, B.P.^1 ; Fajarningsih, N.D.^2 ; Yusro, N.F.^2 ; Sari, A.M.^1 ; Nursiwi, A.^1 ; Praseptiangga, D.^1 ; Yunus, A.^3

Department of Food Science and Technology, Sebelas Maret University (UNS), Jl. Ir. Sutami 36 A, Kentingan, Surakarta

57126, Indonesia^1

Research and Development Center for Marine and Fisheries Product Competitiveness and Biotechnology, Ministry of Marine Affairs and Fisheries, Jl. KS Tubun Petamburan VI, Slipi, Jakarta, Indonesia^2

Graduate School Program of Sebelas Maret University (UNS), Jl. Ir. Sutami 36 A, Kentingan, Surakarta

57126, Indonesia^3

关键词: Anti-tumor activities;    Binding specificities;    Cancer cells;    Carbohydrate binding;    Cervical cancer cells;    Macro-algae;    Marine algae;    Mitogenic activity;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/193/1/012017/pdf
DOI  :  10.1088/1757-899X/193/1/012017

来源: IOP

【 摘 要 】

Lectins or carbohydrate-binding proteins, are widely distributed in nature, including in marine algae. It may have been considered that binding specificity of lectins to some carbohydrates provokes to produce many unique biological activities, including cell agglutination, mitogenic activity, and antitumor activity. The aim of this study was to determine the cytotoxicity of crude lectins from red macroalgae collected from the southern coast of Java Island, Gunung Kidul Regency, Yogyakarta against MCF-7 and HeLa cancer cells. In vitro MTT assay was used in this study. The results showed that less than 50% of MCF-7 and HeLa cancer cells growth were inhibited by the crude lectins from five species of red macro algae used in this study. The highest inhibition ability shown in the red alga A. nana was able to kill 47.68% of HeLa cervical cancer cells.