Hydrogels based on polysaccharide-calcium phosphate with antibacterial / antitumor activity for 3D printing

3rd International Youth Scientific Forum with International Participation "New Materials"

Teterina, A. Yu^1 ; Fedotov, A. Yu^1 ; Zobkov, Yu V.^1 ; Sergeeva, N.S.^2 ; Sviridova, I.K.^2 ; Kirsanova, V.A.^2 ; Karalkin, P.A.^2 ; Komlev, V.S.^1

A.A. Baikov Institute of Metallurgy and Material Sciences, Russian Academy of Science, Moscow

119334, Russia^1

P.A. Herzen Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Centre, Ministry of Health Care of the Russian Federation, Moscow

125284, Russia^2

关键词: 3-D printing;    Anti-tumor activities;    Bone substitutes;    Drug release kinetics;    Malignant disease;    Osteoconductive;    Physicochemical characteristics;    Specific activity;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/347/1/012044/pdf
DOI  :  10.1088/1757-899X/347/1/012044

来源: IOP

【 摘 要 】

The purpose of this study was to develop hydrogels for 3D printing of sodium alginate/gelatin/octacalcium phosphate-based constructs with antibacterial and antitumor activity intended for bone defects replacement in patients with malignant diseases. In this work, we evaluated the drug release kinetic and physico-chemical characteristics of constructs, as well as their specific activity, biocompatibility and osteoplastic properties by means of in vitro and in vivo tests. The principal possibility of creating the biocompatible bone substitutes with antibacterial/antitumor activity and osteoconductive-retaining properties of 3D printing method was demonstrated.