Antioxidant and Cytotoxic Activity of Phyllanthus acidus Fruit Extracts

3rd International Seminar On Sciences "Sciences On Precision And Sustainable Agriculture"

Andrianto, D.^1 ; Widianti, W.^1 ; Bintang, M.^1

Biochemistry Department, Bogor Agricultural University, Bogor, Indonesia^1

关键词: Anti-oxidant activities;    Biological potency;    Brine shrimp lethalities;    Cytotoxic activities;    Ethanol extract;    Extraction yield;    Indonesian plants;    Solvent-extraction process;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/58/1/012022/pdf
DOI  :  10.1088/1755-1315/58/1/012022

来源: IOP

【 摘 要 】

Phyllanthus acidus is an Indonesian plant belonging to the Euphorbiaccae family. Extraction of P. acidus was performed using the maceration method. Four-solvent extraction process by ethanol, 70% ethanol, 30% ethanol, and water was used. The antioxidant activity from this extract was determined using 2,2-diphenyl-1-pikrilhidrazil (DPPH) and cytotoxicity (biological potency from this extract) using Brine Shrimp Lethality Test (BSLT) method. We found that the extraction yields of samples ranging from 1.13% to 20.25%. The ethanol extract showed the highest yield, while the lowest yield was reported in the water extract of P. acidus fruit. Among the samples, water extract of P. acidus exhibited high antioxidant activity with IC5026.06 μg/mL. LC50values for BSLT ranging from 473.26 to 908.98 μg/mL, with the water extract having the lowest value and therefore the most potent, and the ethanol extract having the highest value.