A Green Synthesis of Chalcones As an Antioxidant and Anticancer

International Conference on Chemistry and Material Science 2017

化学;材料科学

Susanti Vh, Elfi^1 ; Eko Setyowati, Widiastuti Agustina^1

Department of Chemistry, FKIP Universitas Sebelas Maret, Surakarta, Indonesia^1

关键词: Anti-oxidant activities;    Cervical cancer cells;    Colorimetric assays;    Cytotoxic activities;    Green chemistry approaches;    Green synthesis;    Radical scavenging;    Stronger activities;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/299/1/012077/pdf
DOI  :  10.1088/1757-899X/299/1/012077

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Three chalcones (4'-amino-4-methoxy chalcone, 4'-amino-3,4-dimethoxy chalcone and 4'-amino-3,4,5-trimethoxy chalcone) has been synthesized by a green chemistry approach using grinding technique. Antioxidant activity of the chalcones were assessed using 1,1-biphenyl-2-picrylhydrazyl (DPPH) radical scavenging method. Cytotoxicity of chalcones sythesized was evaluated using a tetrazolium (MTT) colorimetric assay against cervical cancer cell line, HeLa. The antioxidant activity test showed that 4'-amino-4-methoxy chalcone had a stronger activity than the 4'-amino-3,4-dimethoxy chalcone and 4'-amino-3,4,5-trimethoxy chalcone, respectively with IC5058.85, 64.79 and 210.3 μg/mL. These results indicate that there is a relationship between the structure of chalcone with antioxidant activity, the more methoxy groups in the ring B of the chalcone, antioxidant activity is getting smaller. The chalcone synthesized showed cytotoxicity against HeLa cell line with IC50value of 31.75, 36.65, 49.04 μg/mL, respectively. It was observed that the highest cytotoxic activity was found at 4'-amino-4-methoxy chalcone (IC5031.75 μg/mL). Lower activity was showed by 4'-amino-3,4,5-trimethoxy chalcone with IC50value of 49,04 μg/mL. There is a relationship cytotoxicity with chalcone structure, the more the number of methoxy groups in ring B chalcone, will decrease the activity of cytotoxicity.