The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon

Memórias do Instituto Oswaldo Cruz

Taís Nóbrega De Sousa¹  Flora Satiko Kano¹  Cristiana Ferreira Alves De Brito¹  Luzia Helena Carvalho¹ 

关键词: malaria;    Plasmodium vivax;    Duffy binding protein;    naturally acquired antibodies;    genetic variability;   

DOI  :  10.1590/0074-0276130592

来源: SciELO

【 摘 要 】

Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (region II, DBPII) and DARC to P. vivax infection has motivated our malaria research group at Oswaldo Cruz Foundation (state of Minas Gerais, Brazil) to conduct a number of immunoepidemiological studies to characterise the naturally acquired immunity to PvDBP in populations living in the Amazon rainforest. In this review, we provide an update on the immunology and molecular epidemiology of PvDBP in the Brazilian Amazon - an area of markedly unstable malaria transmission - and compare it with data from other parts of Latin America, as well as Asia and Oceania.

【 授权许可】

CC BY   
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