Duffy‐null promoter heterozygosity reduces DARC expression and abrogates adhesion of the P. vivax ligand required for blood‐stage infection

FEBS Letters

Kastens, W²  Adams, John H³  Michon, Pascal³  Wood, Erica M¹  Zimmerman, Peter A²  Woolley, Ian² 

[1] American Red Cross Blood Services, Northern Ohio Region, Cleveland, OH 44115, USA;Division of Geographic Medicine, Case Western Reserve School of Medicine and University Hospitals of Cleveland, 2109 Adelbert Road, Cleveland, OH 44106-4983, USA;Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556-0369, USA

关键词: Malaria;    Duffy binding protein;    Duffy antigen receptor for chemokines;    Genetic selection;    Plasmodium vivax;    DARC;    Duffy antigen receptor for chemokines;    DBP;    Duffy binding protein;    EBA-175;    erythrocyte binding protein-175;    HSVgD1;    herpes simplex virus glycoprotein D1;   

DOI  :  10.1016/S0014-5793(01)02370-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The Duffy blood group antigen is an essential receptor for Plasmodium vivax entry into erythrocytes in a process mediated by the parasite ligand, the Duffy binding protein (DBP). Recently, individuals living in a malaria endemic region of Papua New Guinea were identified as heterozygous for a new allele conferring Duffy negativity, which results in 50% less Duffy antigen on their erythrocytes. We demonstrate that DBP adherence to erythrocytes is significantly reduced for erythrocytes from heterozygous individuals who carry one Duffy antigen negativity allele. These data provide evidence that emergence of this new allelic form of Duffy negativity is correlated with resistance against vivax malaria.

【 授权许可】

Unknown