New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix

International Journal of Molecular Sciences

Ya-Yuan Lai²  Li-Chai Chen⁴  Chug-Fung Wu⁷  Mei-Chin Lu²  Zhi-Hong Wen¹  Tung-Ying Wu⁶  Lee-Shing Fang⁵  Li-Hsueh Wang²  Yang-Chang Wu⁶  Ping-Jyun Sung²  Vassilios Roussis³ 

[1] Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mail:;Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; E-Mails:Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan;;Department of Pharmacy of Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan; E-Mail:;Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan; E-Mail:;Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan; E-Mail:;Division of Surgical Oncology, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan; E-Mail:

关键词: Ircinia felix;    sponge;    homoscalarane;    sesterterpenoid;    cytotoxicity;   

DOI  :  10.3390/ijms160921950

来源: mdpi

【 摘 要 】

Two new 24-homoscalarane sesterterpenoids, felixins F (1) and G (2), were isolated from the sponge Ircinia felix. The structures of new homoscalaranes 1 and 2 were elucidated by extensive spectroscopic methods, particularly with one-dimensional (1D) and two-dimensional (2D) NMR, and, by comparison, the spectral data with those of known analogues. The cytotoxicity of 1 and 2 against the proliferation of a limited panel of tumor cell lines was evaluated and 1 was found to show cytotoxicity toward the leukemia K562, MOLT-4, and SUP-T1 cells (IC₅₀ ≤ 5.0 μM).

【 授权许可】

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.