Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.

Marine Drugs

Yu-Chia Chang³  Shang-Wei Tseng³  Li-Lian Liu¹  Yalan Chou¹  Yuan-Shing Ho²  Mei-Chin Lu³ 

[1] Institute of Marine Biology, National Sun Yat-sen University, Kaohsiung 804, Taiwan;Eastern Marine Biology Research Center, Fisheries Research Institute, Taitung 961, Taiwan;National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan;

关键词: sesterterpenoid;    scalarane;    sponge;    Hippospongia;   

DOI  :  10.3390/md10050987

来源: mdpi

【 摘 要 】

One new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane–type sesterterpenes (3–8), were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. These metabolites are the first pentacyclic sesterterpene and scalarane-type sesterterpenes to be reported from this genus. Compounds 3–5 exhibited significant cytotoxicity against DLD-1, HCT-116, T-47D and K562 cancer cell lines.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.