Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.

International Journal of Molecular Sciences

Yeon-Ju Lee²  Jeong-Woo Lee²  Dong-Geun Lee²  Hyi-Seung Lee²  Jong Soon Kang¹  Jieun Yun¹ 

[1] Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon 323-833, Korea; E-Mails:;Marine Natural Product Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Ansan 426-744, Korea; E-Mails:

关键词: sponge;    Scalarispongia;    sesterterpenoid;    scalarane;    cytotoxicity;   

DOI  :  10.3390/ijms151120045

来源: mdpi

【 摘 要 】

Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI₅₀ values down to 5.2 μM) against six human cancer cell lines.

【 授权许可】

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.