Contribution of BDNF-Mediated Inhibition in Patterning Avian Skin Innervation

Developmental Biology

Sheryl A. Scott¹  Sharon M. Cahoon-Metzger¹  Guoying Wang¹ 

[1] Department of Neurobiology and Anatomy, Program in Neuroscience, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, Utah, 84132

关键词: skin;    development;    chick;    BDNF;    sensory innervation;    cutaneous;    inhibition;   

DOI  :  10.1006/dbio.2001.0172

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Multiplefactorsareinvolvedinthedevelopmentandregulationofsensoryinnervationinskin.Thefindingswereportheresuggestthatbrain-derivedneurotrophicfactor(BDNF)-mediatedinhibitionmayplayanimportantroleindeterminingthepatternofsensoryinnervationinavianskin.Inbirds,cutaneousinnervationisrestrictedtodermis,whereaxonsformaringofinnervationaroundthebaseofeachfeather.HereweshowthatbothBDNFmessageandproteinaremoreabundantinavianepidermisthandermiswheninnervationisbeingestablished;theBDNFindermisislocalizedtofeatherbuds.Invitro,BDNFcausedgrowthconesofNGF-dependentdorsalrootganglionneuronstocollapse.Similarly,outgrowthofneuritestowardBDNF-secretingfibroblastswasinhibited.TheinhibitoryeffectsofBDNFappeartobemediatedbythelow-affinityp75neurotrophinreceptor,ratherthanatrkreceptor.Thus,thedistributionofBDNFinembryonicavianskinandtheinhibitoryeffectsofBDNFoncutaneousneuritesinvitrosuggestthatBDNFmaybeimportantinrestrictingaxonsfromenteringtheepidermisandthecoreoffeatherbudsduringdevelopmentinvivo.

【 授权许可】

Unknown