A Reciprocal Relationship between Cutaneous Nerves and Repairing Skin Wounds in the Developing Chick Embryo

Developmental Biology

Steven Harsum¹  Paul Martin¹  Jonathan D.W. Clarke¹ 

[1] Department of Anatomy and Developmental Biology, University College London, Gower Street, London, United Kingdom, WC1E 6BT

关键词: wound healing;    chick;    embryo;    skin;    sensory nerves;    hyperinnervation;   

DOI  :  10.1006/dbio.2001.0395

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Variousstudieshavesuggestedthattherateofadultskinhealingmaybeinsomewaydependentonsignalsemanatingfromcutaneousnerves.Further,itappearsthatadultwoundsbecomehyperinnervatedbysensorynervesduringtheprocessofhealing.Inordertoinvestigatethisreciprocalrelationshipfurther,wehaveusedasimpleembryonicmodeltolookattheeffectofwoundsonnerves,andconversely,theeffectofnervesonwounds.Wefindthatwoundsmadetothedorsumofthechickwingbud,atastagepriortonormalinnervation(atE4),orsoonafterthenormalestablishmentofcutaneousinnervation(atE7),subtlyalterthepatternofbranchingbyperturbingdevelopmentalguidancecues,butdonotcausehyperinnervation,whereaswoundingatE14doescausehyperinnervation.Bycreatingchickswithnervelesswings,weshowthatfromE7,woundhealingintheabsenceofnervesissignificantlyimpaired.Theseobservationssuggestthat,fromtheearlieststagesofskininnervation,thepresenceofnervesisbeneficialtothehealingprocess,butthat,incontrasttoneonatalandadulttissues,woundhealingintheembryoandearlyfoetusdoesnottriggerhyperinnervation.

【 授权许可】

Unknown