Developmental Biology | |
Development of “Normal” Dermatomes and Somatotopic Maps by “Abnormal” Populations of Cutaneous Neurons | |
Sheryl A. Scott1  Guoying Wang1  | |
[1] Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah, 84132 | |
关键词: dorsal root ganglia; chick; hindlimb; sensory; development; dorsal horn; somatotopy; central projections; | |
DOI : 10.1006/dbio.2002.0824 | |
学科分类:生物科学(综合) | |
来源: Academic Press | |
【 摘 要 】
Duringdevelopment,motorandsensoryaxonsgrowtoperipheraltargetswithremarkableprecision.Whereasmuchhasbeenlearnedaboutthedevelopmentofmotoneuronconnectivity,lessisknownabouttheregulationofcutaneousinnervation.Inadults,dorsalrootganglia(DRG)innervatecharacteristicskinregions,termeddermatomes,andtheiraxonsprojectsomatotopicallyinthedorsalhorn.Here,wehaveinvestigatedwhethercutaneousneuronsareselectivelymatchedwithspecificskinregions,andwhetherperipheraltargetskininfluencesthecentralconnectionsofcutaneousneurons.Toaddressthesequestions,weshiftedlimbbudsrostrallyinchickembryospriortoaxonoutgrowth,causingDRGstoinnervatenovelskinregions,andmappedtheresultingdermatomesandcentralprojections.Followinglimbshifts,cutaneousinnervationarosefrommorerostralandfromfewerDRGsthannormal,buttheoveralldermatomepatternwaspreserved.Thus,DRGsparceloutinnervationofskininaconsistentmanner,withnoindicationofmatchingbetweenskinandDRGs.Similarly,cutaneousnervesestablisheda“normalâ€somatotopicmapinthedorsalhorn,butinmorerostralsegmentsthanusual.Thus,theperipheraltargetskinmayinfluencethepatternofCNSprojections,butdoesnotdirectcutaneousaxonstospecificpopulationsofneuronsinthedorsalhorn.
【 授权许可】
Unknown
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