Ionic liquid-mediated three-component synthesis of fluorinated spiro-thiazine derivatives and their antimycobacterial and DNA cleavage activities

Journal of Chemical Sciences

Deepti Saini¹  Ruby Singh¹  Anshu Dandia1¹ 

[1] Department of Chemistry, University of Rajasthan, Jaipur 302 004, India$$

关键词: Environmentally benign;    spiro-thiazine derivative;    tandem reaction;    antimycobacterial activity;    DNA scavenging activity.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A simple, green and catalyst-free novel protocol is developed for the synthesis of medicinally important spiro[indole-3,2'[1,3]-thiazine]-2,4'-dione and spiro[acenaphthylene-1,2'-[1,3]thiazine]dione libraries by the tandem reaction of readily available reagents in 1-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6]. The ionic liquid has been used as a solvent as well as catalyst for this reaction. This reaction proceeded smoothly in good to excellent yields and offered several other advantages including short reaction time, simple experimental workup procedure and no by-products. The synthesized compounds were subjected to antimycobacterial efficacy against Mycobacterium tuberculosis H37Rv strain and DNA cleavage activity.

【 授权许可】

Unknown