Synthesis of Indoles by Reductive Cyclization of 2-(2-Nitroaryl)acetonitriles in the Presence of Active and Recyclable Co-Rh Heterobimetallic Nanoparticle Catalyst

heterogeneous catalysis;hydrogenation;reductive cyclization;indoles;azaindoles;tandem reaction;mild condition;540

자연과학대학 화학부 ;

University:서울대학교 대학원

关键词: heterogeneous catalysis;    hydrogenation;    reductive cyclization;    indoles;    azaindoles;    tandem reaction;    mild condition;    540;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/134951/1/000000141855.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

A cobalt-rhodium heterobimetallic nanoparticle-catalyzed reductive cyclization of 2-(2-nitroaryl)acetonitriles to indoles has been achieved. The tandem reaction proceeds without any additives under the mild conditions (1 atm H2 and 25 oC). This procedure could be scaled up to the gram scale. The catalytic system is significantly stable under these reaction conditions and could be reused more than ten times without loss of catalytic activity.