Base Catalysed Pyrimidine Synthesis Using Microwave

Bulletin of the Korean chemical society

M. Kidwai¹  S. Rastogi¹  S. Saxena¹ 

关键词: Pyrimidine;    SBT;    Microwave irradiation;    Alumina;    Environmentally benign;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

An environmentally benign approach for the synthesis of 2-substituted-4,6-diaryl pyrimidines using inorganic solid supports for its catalytic role as well as an energy transfer medium is described. The methodology eliminates the usage of solvent during the reaction. The reaction time is brought down from hours to minutes along with yield enhancement. The rate enhancement and high yield is attributed to the coupling of solvent free conditions with microwaves. Further, the role of base is studied in the reaction and it is concluded that microwave assisted basic alumina catalysed reaction is the best in terms of catalysis as well as reaction time and yield.

【 授权许可】

Unknown