Fragmentation of DNA in P388D1 macrophages exposed to oxidised low‐density lipoprotein

FEBS Letters

Reid, Vanessa C.¹  Hardwick, Simon J.¹  Mitchinson, Malcolm J.¹ 

[1] Division of Cellular Pathology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 IQP, UK

关键词: Oxidised LDL;    Macrophage;    DNA fragmentation;    Apoptosis;    Atherosclerosis;   

DOI  :  10.1016/0014-5793(93)80635-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Exposing a macrophage-like murine cell line to copper-oxidised low-density lipoprotein led to DNA fragmentation which was inhibited by the putative Ca²⁺/Mg²⁺ endonuclease inhibitor, zinc sulphate. DNA fragmentation preceded loss of membrane impermeability. These results suggest that apoptosis may be a mechanism of macrophage foam cell death in atherosclerotic lesions in the arterial wall.

【 授权许可】

Unknown