Murine ST2 gene is a member of the primary response gene family induced by growth factors

FEBS Letters

Tsukamoto, Toshihiko¹  Yanagisawa, Ken¹  Tominaga, Shin-ichi¹  Takagi, Toshimitsu¹ 

[1] Department of Biochemistry II, Jichi Medical School, Tochigi, Japan

关键词: Cell cycle;    Primary response gene;    Interleukin 1 receptor;    immunoglobulin superfamily;    Cell growth;    IL-1R1;    interleukin 1 receptor type 1;    IL-1R2;    interleukin 1 receptor type 2;    β-IFN;    β-interferon;    CHX;    cycloheximide;    dCTP;    deoxycytidine 5′-triphosphate;    DME;    Dulbecco's modified Eagle's medium;   

DOI  :  10.1016/0014-5793(92)80282-L

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The murine ST2 gene, which encodes a protein remarkably similar to the extracellular portion of murine interleukin 1 receptor types 1 and 2, is expressed in growth-stimulated BALB/c-3T3 cells in the presence of 50 μg/ml of cycloheximide. The treatment with 1,000 U/ml of purified native murine β-interferon superinduced, rather than suppressed, the ST2 mRNA expression as in the cases or c-myc and JE mRNAs. These results suggested that the murine ST2 gene belongs to the family of primary response genes induced by growth factors. Furthermore, a longer ST2-related mRNA was found in BALB/c-3T3 cells that were stimulated to proliferate in the presence of cycloheximide.

【 授权许可】

Unknown