The structure of protein phosphatase 2A is as highly conserved as that of protein phosphatase I

FEBS Letters

Dudai, Yadin¹  Alphey, Luke²  Axton, J.Myles²  Brewis, Neil D.³  Orgad, Sara¹  Cohen, Patricia T.W.³ 

[1] Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel;CRC Cell Cycle Genetics Group, Department of Biochemistry, The University, Dundee, DD1 4HN, Scotland UK;MRC Protein Phosphorylation Group, Department of Biochemistry, The University, Dundee, DD1 4HN, Scotland UK

关键词: Protein phosphatase;    cDNA cloning;    Nucleotide sequence;    Amino acid sequence;    Sequence homology;    Drosophila melanogaster;   

DOI  :  10.1016/0014-5793(90)81435-Q

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

cDNA coding for protein phosphatase 2A (PP2A) has been isolated from Drosophila head and eye imaginal disc libraries. Drosophila PP2A mRNA is expressed throughout development, but is most abundant in the early embryo. The cDNA hybridises to a single site on the left area of the second chromosomes at position 28D2-4. The deduced amino acid sequence (309 residues) of Drosophila PP2A shows 94% identity with either rabbit PP2Aα or PP2Aβ, indicating that PP2A maybe the most conserved of all known enzymes.

【 授权许可】

Unknown