A second catalytic subunit of type‐2A protein phosphatase from rabbit skeletal muscle

FEBS Letters

da Cruz e Silva, Odete B.¹  Cohen, Patricia T.W.¹ 

[1] Department of Biochemistry, Medical Sciences Institute, University of Dundee, Dundee DD1 4HN, Scotland

关键词: Protein phosphatase;    cDNA cloning;    Nucleotide sequence;    Amino acid sequence;    Isozyme;   

DOI  :  10.1016/0014-5793(87)80574-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A cDNA clone encoding a second type-2A protein phosphatase catalytic subunit (2A_β) was isolated from a rabbit skeletal muscle cDNA library constructed in λgt10. The deduced protein sequence (309 residues, 35.59 kDa) was 97% identical to that of phosphatase 2A_α(309 residues, 35.58 kDa). At the nucleotide level, the two clones showed only 82% identity in the coding region. The results indicate the presence of at least two isoforms of protein phosphatase 2A in skeletal muscle.

【 授权许可】

Unknown