Subcellular distribution of acetylcholinesterase asymmetric forms during postnatal development of mammalian skeletal muscle

FEBS Letters

Fernandez, Hugo L.¹  Seiter, Thomas C.¹ 

[1] Neuroscience Research Laboratory, Veterans Administration Medical Center, Kansas City, MO 64128, USA

关键词: Acetylcholinesterase;    Postnatal development;    Neuromuscular junction;    Skeletal muscle;    Subcellular distribution;    Cholinesterase inhibitor;   

DOI  :  10.1016/0014-5793(84)81388-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

This study describes the changes which occur in intra- and extracellular asymmetric acetylcholinesterase (AChE) forms in rat gracilis muscle during postnatal development. Initially (day 7) these forms (12.5 S and 16 S AChE) were evenly distributed along the muscle and only present intracellularly. With advancing age (days 7–28) they gradually became concentrated in endplate (vs non-endplate) muscle regions where a certain proportion of them was subsequently externalized. In contrast, no externalization was observed in the non-endplate regions. Our results support the view that AChE asymmetric forms are assembled within the muscle cell prior to their deposition on the extracellular synaptic compartment.

【 授权许可】

Unknown