The Study of Doxorubicin and its Interaction with Adenine by UV-Resonance Raman Spectroscopy

Journal of the Korean Chemical Society

Chul-Jae Lee¹  Maeng-Joon Jung¹ 

关键词: Ç¥¸éÁõ°­ ¶ó¸¸ ºÐ±¤¹ý;    Doxorubicin;    Adenine;    Guanine;    UV-Resonance Raman Spectroscopy;    Surface Enhanced Raman Spectroscopy;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The interaction of the antitumour agent, doxorubicin, with adenine is investigated in an aqueous solution at a concentration of 10-3~10-4 with volume ratios of 1:2. A UV-resonance Raman spectroscopy and surface enhanced Raman spectroscopy are used to determine the binding sites of doxorubicin to adenine and the structural variations of doxorubicin-adenine complexes in an aqueous solution. We identified that the possibilities of doxorubicin interacted with the N7 positions of adenine.

【 授权许可】

Unknown