Effect of tween 80 on nanoparticle preparation of modified chitosan for targeted delivery of combination doxorubicin and curcumin analogue

2017 International Conference on Sensors, Materials and Manufacturing

工业技术;材料科学;机械制造

Sukmawati, Anita^1 ; Utami, Wahyu^1 ; Yuliani, Ratna^1 ; Da'I, Muhammad^1 ; Nafarin, Akhmad^1

Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Pabelan Surakarta

57162, Indonesia^1

关键词: Active substance;    Curcumin;    Doxorubicin;    Ionic gelation method;    Modified chitosan;    Nano-size particles;    Nanoparticle preparations;    Targeted delivery;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/311/1/012024/pdf
DOI  :  10.1088/1757-899X/311/1/012024

来源: IOP

【 摘 要 】

Delivery of anticancer is facing several problems including unspecific delivery of active substance to the targeted cell. The conjugation between chitosan and folate (chitosan-FA) was used for nanoparticle preparation containing combination of doxorubicin (DOX) and curcumin analogue, 2,5-bis-(4-hydroxi,3,5-dimethyl)-benzylidincylopentanone, as active substances. The purpose of this research is investigating formulation aspect for chitosan-FA nanoparticle by addition various tween 80 to achieve desired nano-size particle. The ionic gelation method was used for nanoparticle preparation using 0.05% w/v chitosan-FA with addition of 0.1 and 0.5% v/v of tween 80. The result showed that the high concentration of tween 80 during nanoparticle preparation lead to formation of smaller size particle. The 111.8 ?4.11 nm particle size was revealed by addition of 0.5% v/v tween 80 during chitosan-FA nanoparticle preparation loaded with active substances.