Ultrasound-aided synthesis of gold-loaded boron-doped graphene quantum dots interface towards simultaneous electrochemical determination of guanine and adenine biomolecules

Ultrasonics Sonochemistry

Patel Nishant Mansukhlal¹  Sambandam Anandan¹  Muthupandian Ashokkumar²  Belqasem Aljafari³  Reshma Kaimal³ 

[1] Solar Energy Conversion Lab, Department of Chemistry, National Institute of Technology, Tiruchirappalli 620015, India;Department of Electrical Engineering, College of Engineering, Najran University, Najran 11001, Saudi Arabia;;Nanomaterials &

关键词: Cyclic voltammetry;    Boron graphene quantum dots;    Gold nanoparticles;    Guanine;    Adenine;   

DOI  :  

来源: DOAJ

【 摘 要 】

To acquire substantial electrochemical signals of guanine-GUA and adenine-ADE present in deoxyribonucleic acid-DNA, it is critical to investigate innovative electrode materials and their interfaces. In this study, gold-loaded boron-doped graphene quantum dots (Au@B-GQDs) interface was prepared via ultrasound-aided reduction method for monitoring GUA and ADE electrochemically. Transmission electron microscopy-TEM, Ultraviolet–Visible spectroscopy-UV–Vis, Raman spectroscopy, X-ray photoelectron spectroscopy-XPS, cyclic voltammetry-CV, and differential pulse voltammetry-DPV were used to examine the microstructure of the fabricated interface and demonstrate its electrochemical characteristics. The sensor was constructed by depositing the as-prepared Au@B-GQDs as a thin layer on a glassy carbon-GC electrode by the drop-casting method and carried out the electrochemical studies. The resulting sensor exhibited a good response with a wide linear range (GUA = 0.5–20 μM, ADE = 0.1–20 μM), a low detection limit-LOD (GUA = 1.71 μM, ADE = 1.84 μM), excellent sensitivity (GUA = 0.0820 µAµM−1, ADE = 0.1561 µAµM−1) and selectivity with common interferents results from biological matrixes. Furthermore, it seems to have prominent selectivity, reproducibility, repeatability, and long-lasting stability. The results demonstrate that the fabricated Au@B-GQDs/GC electrode is a simple and effective sensing platform for detecting GUA and ADE in neutral media at low potential as it exhibited prominent synergistic impact and outstanding electrocatalytic activity corresponding to individual AuNPs and B-GQDs modified electrodes.

【 授权许可】

Unknown