Final Report on Grant DE-FG02-04ER63801: Damage Recognition, Protein Signaling and Fidelity of Base Excision Repair

Miller, John H.

Washington State University

关键词: DNA damage;    Guanine;    DNA;    63 Radiation, Thermal, And Other Environ. Pollutant Effects On Living Orgs. And Biol. Mat.;    Oxidation;   

DOI  :  10.2172/859301
RP-ID  :  DOE/ER/63801-1
RP-ID  :  FG02-04ER63801
RP-ID  :  859301

美国|英语

来源: UNT Digital Library

【 摘 要 】

Research funded by grant DE-FG02-04ER63801 focused on DNA hydration modeled by classical molecular dynamics (MD) simulation. The most important finding of our research was that oxidation of guanine, a ubiquitous DNA lesion caused by endogenous and environmental oxidative stress, changes DNA hydration in a way that increases the stability of the damage base pair.