Enrichment of Nanodiamond Surfaces with Carboxyl Groups for Doxorubicin Loading and Release

11th Joint Conference on Chemistry in Conjunction with the 4th Regional Biomaterials Scientific Meeting

材料科学;化学;生物科学

Astuti, Y.^1 ; Saputra, F.D.^1 ; Wuning, S.^1 ; Arnelli^1 ; Bhaduri, G.^2

Chemistry Department, Science and Mathematics Faculty, Diponegoro University, Central Java

50275, Indonesia^1

School of Chemical Engineering and Advanced Materials, Newcastle University, United Kingdom^2

关键词: Carboxyl groups;    Doxorubicin;    Drug loading;    Release Efficiency;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/172/1/012066/pdf
DOI  :  10.1088/1757-899X/172/1/012066

来源: IOP

【 摘 要 】

In their pristine state, nanodiamond crystals produced via detonation techniques containing several functional groups present on the surface including amine, amide, alcohol, carbonyl, and carboxyl. These functional groups facilitate nanodiamond to interact drugs so as to nanodiamond is potential for medical application such as drug delivery. Even though research on t he use of nanodiamond for this application has been conducted widely, research on the effect of enrichment of nanodiamond surface with carboxyl functional groups for drug loading and release has not been explored extensively. Therefore, in this paper, the effect of carboxyl-terminated nanodiamond (ND-COOH) on drug loading and release will be presented. The enrichment of nanodiamond with carboxyl groups was undertaken by treating nanodiamond with sulphuric acid and nitric acid. The results show that the doxorubicin (DOX) loading and release efficiencies of ND pristine are higher than that of ND-COOH.