Biocompatible FePO4 Nanoparticles: Drug Delivery, RNA Stabilization, and Functional Activity

Nanoscale Research Letters

Sagar Rayamajhi¹  Santosh Aryal²  Sarah Wilson³  Robert DeLong³ 

[1] Department of Chemistry, Kansas State University, 66502, Manhattan, KS, USA;Nanotechnology Innovation Center of Kansas State, College of Veterinary Medicine, Kansas State University, 66502, Manhattan, KS, USA;Department of Pharmaceutical Sciences and Health Outcomes, The Ben and Maytee Fisch College of Pharmacy, The University of Texas at Tyler, 75799, Tyler, TX, USA;Nanotechnology Innovation Center of Kansas State, College of Veterinary Medicine, Kansas State University, 66502, Manhattan, KS, USA;

关键词: Iron phosphate nanoparticles;    Doxorubicin;    Drug delivery;    Drug loading;    RNA stabilization;    Biocompatible nanoparticles;   

DOI  :  10.1186/s11671-021-03626-8

来源: Springer

【 摘 要 】

FePO4 NPs are of special interest in food fortification and biomedical imaging because of their biocompatibility, high bioavailability, magnetic property, and superior sensory performance that do not cause adverse organoleptic effects. These characteristics are desirable in drug delivery as well. Here, we explored the FePO4 nanoparticles as a delivery vehicle for the anticancer drug, doxorubicin, with an optimum drug loading of 26.81% ± 1.0%. This loading further enforces the formation of Fe3+ doxorubicin complex resulting in the formation of FePO4-DOX nanoparticles. FePO4-DOX nanoparticles showed a good size homogeneity and concentration-dependent biocompatibility, with over 70% biocompatibility up to 80 µg/mL concentration. Importantly, cytotoxicity analysis showed that Fe3+ complexation with DOX in FePO4-DOX NPs enhanced the cytotoxicity by around 10 times than free DOX and improved the selectivity toward cancer cells. Furthermore, FePO4 NPs temperature-stabilize RNA and support mRNA translation activity showing promises for RNA stabilizing agents. The results show the biocompatibility of iron-based inorganic nanoparticles, their drug and RNA loading, stabilization, and delivery activity with potential ramifications for food fortification and drug/RNA delivery.

【 授权许可】

CC BY