Synergistic Cytotoxicity Effect by Combination Treatment of Polyketide Derivatives from Annona muricata Linn Leaves and Doxorubicin as Potential Anticancer Material on Raji Cell Line

International Conference on Advanced Materials for Better Future 2017

Artanti, A.N.^1 ; Astirin, O.P.^2 ; Prayito, A.^3 ; Fisma, R.^2 ; Prihapsara, F.^1

Department of Pharmacy, Faculty of Mathematic and Natural Sciences, Sebelas Maret University, Surakarta, Indonesia^1

Department of Biology, Faculty of Mathematic and Natural Sciences, Sebelas Maret University, Surakarta, Indonesia^2

Department of Pathobiology, Faculty of Medical, Sebelas Maret University, Surakarta, Indonesia^3

关键词: Anti-cancer agents;    Chemotherapeutic agents;    Combination treatments;    Cytotoxicity effects;    Doxorubicin;    Polyketides;    Side effect;    Synergistic effect;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/333/1/012067/pdf
DOI  :  10.1088/1757-899X/333/1/012067

来源: IOP

【 摘 要 】

Nasopharynx cancer is one of the most deadly cancer. The main priority of nasopharynx cancer treatment is the use of chemotherapeutic agents, especially doxorubicin. However, doxorubicin might also lead to diverse side effect. An approach recently develop to overcome side effect of doxorubicin is to used of combined chemotherapeutic agent. One of the compounds found effication as an anticancer agent on nasopharynx cancer is acetogenin, a polyketide compound that is abundant in Annona muricata L. leaves. This study has been done to examine polyketide derivatives was isolated from Annona muricata L. which has potency to induce apoptosis by p53 expression on raji cell line. The determination of cytotoxic combination activity from polyketide derivative and doxorubicin was evaluated using MTT assay to obtain the value of CI (combination index). Data analysis showed that combination of polyketide derivative from Annona muricata L. (14,4 μg/ml) and doxorubicin with all of concentration performed synergistic effect on raji cell line with CI value from 0.13 - 0.65.