The expression and clinical significance of miR-132 in gastric cancer patients

Diagnostic Pathology

Yanong Wang¹  Hong Cai¹  Hongmei Yu¹  Xiaowen Liu¹ 

[1] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

关键词: Biological markers;    Prognosis;    Gastric cancer;   

Others  :  802416
DOI  :  10.1186/1746-1596-9-57

 received in 2014-01-25, accepted in 2014-03-03,  发布年份 2014

【 摘 要 】

Background and objective

miR-132 plays a role in regulating neuronal morphology and cellular excitability. Little is known about the effects of miR-132 in cancer. The aim of this study is to evaluate the expression of miR-132 and its clinical significance in gastric cancer.

Methods

Cancerous tissues and corresponding normal tissues from 79 patients with gastric cancer were examined for the expression of miR-132 using quantitative PCR and the association between miR-132 expression levels and clinicopathological factors and prognosis was analyzed.

Results

In 79 clinical samples of gastric cancer patients, miR-132 expression levels in cancer tissues were significantly higher than those in the corresponding normal tissues (P = 0.001). Higher expression levels of miR-132 were associated with more frequent lymph node metastasis (P = 0.033), more lymphatic tumor emboli (P = 0.007), and more advanced stage (P = 0.016). Additionally, expression of miR-132 was an independent prognostic factor for overall survival (P = 0.020).

Conclusion

miR-132 could serve as an efficient prognostic factor for gastric cancer patients.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8168577241196050 webcite

【 授权许可】

   
2014 Liu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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