Predictive value of preoperative serum CCL2, CCL18, and VEGF for the patients with gastric cancer

BMC Clinical Pathology

Yanong Wang¹  Xiaowen Liu¹  Jianghong Wu¹ 

[1] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

关键词: Biological markers;    Diagnosis;    Gastric cancer;   

Others  :  1084966
DOI  :  10.1186/1472-6890-13-15

 received in 2012-11-30, accepted in 2013-05-16,  发布年份 2013

【 摘 要 】

Background

To investigate the expression of chemokine ligand 2 (CCL2), chemokine ligand 18 (CCL18), and vascular endothelial growth factor (VEGF) in peripheral blood of patients with gastric cancer and their correlation with presence of malignancy and disease progression.

Methods

Sixty patients with pathological proved gastric cancer were prospectively included into study. The levels of CCL2, CCL18, and VEGF in peripheral blood were examined by enzyme-linked immunosorbentassay (ELISA). Peripheral blood from 20 healthy people was examined as control.

Results

The preoperative serum levels of CCL2, CCL18 and VEGF in gastric cancer patients were significantly higher than that of controls (P <0.001, P <0.001, and P <0.001, respectively). ROC curve analysis showed that with a cut-off value of ≥1272.8, the VEGF*CCL2 predicted the presence of gastric cancer with 83% sensitivity and 80% specificity. Preoperative serum CCL2 was significantly correlated to N stage (P =0.040); CCL18 associated with N stage (P =0.002), and TNM stage (P =0.002); VEGF correlated to T stage (P =0.000), N stage (P =0.015), and TNM stage (P =0.000).

Conclusion

Preoperative serum levels of CCL2 and VEGF could play a crucial role in predicting the presence and progression of gastric cancer.

【 授权许可】

   
2013 Wu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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