Differences of serum procalcitonin levels between bacterial infection and flare in systemic lupus erythematosus patients

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Patrick, J.^1,3 ; Marpaung, B.^1,3 ; Ginting, Y.^2,3

Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^1

Division of Tropical Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^2

Haji Adam Malik General Hospital, Medan, Indonesia^3

关键词: Antibiotic therapy;    Bacterial infections;    Biological markers;    Clinical symptoms;    Cross-sectional study;    Procalcitonin;    Serum levels;    Systemic lupus erythematosus;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012157/pdf
DOI  :  10.1088/1755-1315/125/1/012157

来源: IOP

【 摘 要 】

Differentiate bacterial infections from flare in SLE patients is difficult to do because clinical symptoms of infection is similar to flare. SLE patients with infection require antibiotic therapy with decreased doses of immunosuppressant while in flare diseases require increased immunosuppressant. Procalcitonin (PCT), a biological marker, increased in serum patients with bacterial infections and expected to be a solution of problem. The aim of this study was to examine the function of PCT serum as marker to differentiate bacterial infection and flare in SLE patients. This cross-sectional study was conducted in Adam Malik Hospital from January-July 2017. We examined 80 patients SLE flare (MEX-SLEDAI>5), screen PCT and culture according to focal infection. Data were statistically analyzed. 80 SLE patients divided into 2 groups: bacterial infection group (31 patients) and non-infection/flare group (49 patients). Median PCT levels of bacterial infection group was 1.66 (0.04-8.45)ng/ml while flare group was 0.12 (0.02-0.81)ng/ml. There was significant difference of serum Procalcitonin level between bacterial infection and flare group in SLE patients (p=0.001). Procalcitonin serum levels can be used as a biomarker to differentiate bacterial infections and flare in SLE patients.