Bcl-2 protein frequency in patients with high-risk diffuse large B-cell lymphoma

Sao Paulo Medical Journal

Abrahão Elias Hallack Neto²  Sheila Aparecida Coelho Siqueira¹  Frederico Luiz Dulley¹  Alfredo Chauobah¹  Marcelo Belesso¹  Rosaura Saboia¹  Milton Artur Ruiz¹  Dalton Alencar Fischer Chamone¹  Juliana Pereira¹ 

[1] ,Universidade Federal de Juiz de Fora Department of Hematology Juiz de Fora,Brazil

关键词: Lymphoma;    Oncogene proteins;    Prognosis;    Biological markers;    Germinal center;    Linfoma;    Proteínas oncogênicas;    Prognóstico;    Marcadores biológicos;    Centro germinativo;   

DOI  :  10.1590/S1516-31802010000100004

来源: SciELO

【 摘 要 】

CONTEXT AND OBJECTIVE: Gene expression and immunohistochemical profiling of diffuse large B-cell lymphoma (DLBCL) have revealed important prognostic subgroups: germinal center B-cell-like (GCB-like) DLBCL and activated B cell-like (ABC-like) DLBCL. Although few reports on high-risk DLBCL are available, the prognosis for the GCB-like subgroup has been shown to be better than that of the ABC-like subgroup. The role of Bcl-2 as a predictor of survival in DLBCL cases is unclear and its expression varies between the two subgroups of DLBCL. In this study, we analyzed the frequency and prognostic impact of Bcl-2 protein expression in high-risk DLBCL cases. DESIGN AND SETTING: Retrospective cohort study among DLBCL patients treated at Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP). METHODS: The prognostic impact of the expression of the proteins CD10, Bcl-6, MUM1 (multiple myeloma oncogene-1) and Bcl-2 on high-risk DLBCL cases was evaluated by means of immunohistochemistry. Seventy-three patients aged 18-60 years were evaluated for all these markers. RESULTS: Twenty-four cases (32.9%) were GCB-like and 49 (67.1%) were ABC-like, with no difference regarding complete remission, disease-free survival or overall survival rates. Twenty-seven patients (37%) showed Bcl-2 expression, which was the only independent factor predicting a worse prognosis for overall survival according to multivariate analysis. CONCLUSION: Bcl-2 protein was expressed in 37% of the high-risk DLBCL patients, without any difference between the ABC-like DLBCL and GCB-like DLBCL cases.

【 授权许可】

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