Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus

BMC Complementary and Alternative Medicine

Vincenzo De Feo¹  Atif Nisar Ahmad⁶  Luigi Aliberti¹  Muhammad Zia-Ul-Haq²  Shakeel Ahmad⁴  Shahzad Zafar Iqbal⁷  Roselina Karim⁷  Masood Sadiq Butt⁵  Muhammad Tauseef Sultan³ 

[1] Department of Pharmacy, University of Salerno, Salerno, Italy;The Patent Office, Karachi, Pakistan;Department of Food Sciences, Bahauddin Zakariya University Multan, Multan, Malaysia;Department of Agronomy, Bahauddin Zakariya University Multan, Multan, Pakistan;National Institute of Food Science & Technology, University of Agriculture, Faisalabad, Pakistan;Department of Pathobiology, Bahauddin Zakariya University Multan, Multan, Pakistan;Faculty of Food Science and Technology, University of Putra Malaysia, Putra, Malaysia

关键词: Oxidative stress;    Hyperglycemia;    Diabetes mellitus;    Traditional uses;    Nigella sativa;   

Others  :  830071
DOI  :  10.1186/1472-6882-14-193

 received in 2013-12-02, accepted in 2014-05-21,  发布年份 2014

【 摘 要 】

Background

Nigella sativa fixed (NSFO) and essential (NSEO) oils have been used to treat diabetes mellitus and its complications. Present study was undertaken to explore and validate these folkloric uses.

Methods

Sprague dawley rats having streptozotocin (STZ) induced diabetes mellitus were used to assess the role of NSFO and NSEO in the management of diabetes complications. Parameters investigated were antioxidant potential, oxidative stress, and the immunity by in vivo experiments.

Results

The results indicated that STZ decreased the glutathione contents (25.72%), while NSFO and NSEO increased the trait significantly (P < 0.05). Experimental diets increased the tocopherol contents (P < 0.01) and enhanced the expression of hepatic enzymes (P < 0.01). Correlation matrix further indicated that antioxidant potential is positively associated (P < 0.05) responsible for the modulation of hepatic enzymes and the decrease of the nitric oxide production thus controlling the diabetes complications.

Conclusions

Overall, results of present study supported the traditional use of N. sativa and its derived products as a treatment for hyperglycemia and allied abnormalities. Moreover, N. sativa fixed and essential oils significantly ameliorate free radicals and improve antioxidant capacity thus reducing the risk of diabetic complications.

【 授权许可】

   
2014 Sultan et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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