Phytochemical constituents and antidiabetic activity of edible marine red seaweed (Halymenia durvilae)

3rd EMBRIO International Workshop on Marine Biodiversity: Understanding, Utilization, Conservation

生态环境科学

Sanger, G.^1 ; Rarung, L.K.^2 ; Damongilala, L.J.^1 ; Kaseger, B.E.^1 ; Montolalu, L.A.D.Y.^1

Department of Technology of Fishery Product, Sam Ratulangi University, Manado, Indonesia^1

Department of Agribisnis of Fishery, Sam Ratulangi University, Manado, Indonesia^2

关键词: Anti diabetics;    Antidiabetic activity;    Antidiabetic effects;    Bioactive compounds;    Diabetes mellitus;    Halymenia durvilae;    Methanol extract;    Pharmaceutical industry;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/278/1/012069/pdf
DOI  :  10.1088/1755-1315/278/1/012069

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

Seaweeds have bioactive compounds with enormous health prospective which interests the pharmaceutical industries. The isolated bioactive compounds of seaweeds have been utilized as drug and food in the world. Phytochemical constituents of seaweeds have an assortment of prospective biological activity, such as antidiabetes. In worldwide the appearance of type two diabetes mellitus (T2DM) as the greatest non-transmittable disease has motivated search for new antidiabetic approaches. The purpose of the research was to determine the phytochemical properties and antidiabetic effect using α-glukosidase on methanol extract, n-hexane, chloroform, and water fraction of marine red algae Halymenia durvilae. The result of this study showed the phyto-constituent of H.durvilae includes steroids, flavonoids and triterpenoids are present in all extracts. Saponins and hyquinones showed their presence only in methanol extract. Alkaloid and tannin were not present in methanol extract and its fractions. H.durvilae on the extract and its fractions had antidiabetic activity. Water fraction had the highest activity to inhibit α-glukosidase (IC50 4.34±0.32 mg mL) followed by chloroform, hexane and methanol extract. Therefore, it can be concluded that H.durvilae could be used as a dietary food source of bioactive compound especially natural antidiabetic compounds.