Preliminary evaluation of the encapsulation of new antidiabetic sulphonylhydrazone and antitumor N-acylhydrazone derivatives using PLGA nanoparticles

4th International Conference on Safe Production and Use of Nanomaterials

Costa, F.N.^1 ; Ibiapino, A.L.^1 ; De Figueiredo, L.P.^1 ; Barreiro, E.J.^2,3 ; Lima, L.M.^2,3 ; Do Amaral, D.N.^2 ; De Castro, C.E.^1 ; Giacomelli, F.C.^1 ; Ferreira, F.F.^1

Centro de Cincias Naturais e Humanas (CCNH), Universidade Federal Do ABC (UFABC), Santo-André, SP, Brazil^1

LASSBio, Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), RJ, Rio de Janeiro, Brazil^2

Graduate Program of Chemistry, Institute of Chemistry, Federal University of Rio de Janeiro (UFRJ), RJ, Rio de Janeiro, Brazil^3

关键词: Anti diabetics;    Bioactive compounds;    Encapsulation efficiency;    Long-term release;    Nanoprecipitation method;    PLGA nanoparticles;    Preliminary experimental data;    Release profiles;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/617/1/012015/pdf
DOI  :  10.1088/1742-6596/617/1/012015

来源: IOP

【 摘 要 】

It has been demonstrated the feasibly of using PLGA nanoparticles to promote the encapsulation of novel anti-diabetic sulphonylhydrazone and antitumor N-acylhydrazone derivatives. The motivation is to further demonstrate the possibility of long-term release of anti-diabetic as well as higher accumulation of the antitumor derivative by using the nanotechnology-based production. The produced nanoparticles were obtained by the nanoprecipitation method, which revealed to be effective in the encapsulation of the bioactive compounds. The determined sizes were in the range of ∼100 nm, which are supposed to be suitable for both potential applications. The preliminary experimental data demonstrated the formation of stable nanosystems and further experiments are underway in order to determine the loading content, encapsulation efficiency and release profile of the hydrophobic bioactive compounds.